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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

China’s official producer price index rose 1.2 per cent year-on-year in October, according to the National Bureau of Statistics, marking the second straight month of rising prices after 53 months of annualised contraction finally ended in September.
英国独立党(UKIP)前领袖杰尔.法拉奇(Nigel Farage)略逊一畴,就是因为事实证明攻破英国基于党派的制度比美国总统选举更难。

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

什么温度的葡萄酒最好喝(图)
我曾经看到经理们因为工作环境大都是男性所以没有雇佣一位女性。他们不会在乎那个女人有多聪明,多厉害。她就是不合适。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

But, despite the incessant warnings from security researchers, many people are still turning to weak, easily guessable passwords to protect their devices.

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

税:每年大约41684美元(约26.7万元)

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

China’s handling of its state reserves of raw materials such as cotton and sugar will be a key factor shaping the direction of agricultural commodities in 2017, according to a major lender to agribusinesses.
……又唱又跳,希望能得到工作。
Ronaldo's monster pay-packet was the result of his eye-watering pound 38.5 million-a-year salary with Spanish giants Real Madrid and endorsement deals with the likes of Nike, watchmaker Tag Heuer and nutrition supplements group Herbalife - themselves worth pound 22 million.
无论是电视剧,还是正在拍摄的电影版本,都是改编自台湾大宇公司旗下著名的角色扮演游戏(RPG)《仙剑奇侠传》系列。这款电子游戏也被许多玩家视为中国最棒的角色扮演游戏。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

目前已经被泄露的照片多达10个G。据《北京日报》12月1日报道,著名在线P2P借贷平台"借贷宝"也和此次事件有关。
人不得不告慰自己,原来如此。
7. The legacy of a celebrated neuroscientist is contested
“…was caught in a big lie on her resume during the meeting.”

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 重庆再出“组合拳”打击炒房
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

发行于2013年的《炫富帮》是一部语带讽刺的犯罪剧情片,记录了一帮好莱坞山高中生的冒险,他们偷到了当地名人的家里。少年们进入梅根·福克斯和帕丽斯·希尔顿这样的偶像家,偷走现金、衣服、手袋和珠宝,用来模仿杂志上让他们羡慕的奢华生活。在朋友圈炫耀战利品的照片后,他们终于被抓进了监狱。

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

vt. 记载,(用文件

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

SIZE: 6,364 square feet
都柏林大学学院(UCD)迈克尔?斯墨菲特商业研究生院(Michael Smurfit Graduate School of Business)的总体进步最大,排名攀升21位至第48名。北京大学(Peking University)光华管理学院(Guanghua School of Management)重回排行榜第38名,去年该院因学员调查反馈率低而未上榜。

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

“尽管我本质上是一名工程师和分析人员,但迄今为止我所做过的最重要的决定都与此无关,它们永远是基于直觉,”他去年在曾就读MBA的杜克大学(Duke University)对一名采访者表示。
试图推动亚洲ETF持续繁荣但迄今未获成功的公司表示,有必要从根本上改革似乎表明,市场将由说服监管机构和客户重塑行业格局的长期努力定义。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

Trump’s trade war with China
要实现有效的电子邮件营销,可不只是偶尔发一封电子文宣邮件那么简单。要想构建一套有效的电子邮件营销战略,你需要一个功能齐全的工具。MailChimp似乎是市面上最佳的此类系统,它提供了各种典雅直观的电邮广告模板、先进的分段功能和营销自动化功能。

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 家居行业设知识产权保护分站
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

as加强+soc社会+ion→社团;联合
据《每日经济新闻》网报道,经过一项最新调查显示,经济和金融类院校毕业生最有'钱'途。国内5大财经类高校毕业生的平均月薪在1万元以上。
8.A New iPhone
n. 失业,失业人数

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

《一位德国女权主义先锋在痛苦中回顾过去》(A Pioneering German Feminist Looks Back in Anguish)

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

“D型人格”最先由荷兰蒂尔堡大学的心理学家Johan Denollet提出。他还设计了一个测试,帮助人们认识自己是否具有D型人格特征。
学习有难度的课程

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

这些担忧给周五开幕、为期两天的G20央行行长和财长会议投下了浓重的阴影。本周国际货币基金组织(IMF)已经警告准备下调其对今年全球增长的预测,称主要经济体需要采取更多举措来刺激增长。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

[kɑ:st]

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
From the themed collection: 发展住房租赁市场特别是长期租赁
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

可口可乐表示,中国消费放缓打击了销售额,而较为疲弱的需求正迫使其降低库存。
《固定电话》
……一边说从来不会让人看到他流汗,一边汗流不止。
vt. 切成薄片,削

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 共有产权养老房重在降成本
Review Article

Influenza neuraminidase: A druggable target for natural products

Uruguay represents a more curious case, in that its players are footballing aristocracy disguised as minnows. Like Belgium, it is a relatively young nation, yet on the field of play the Uruguayans are old hands. They have won the World Cup twice, first at the inaugural event in 1930, and then in 1950, when Brazil hosted the tournament. The latter occasion, when Brazil succumbed in front of a world-record 200,000 fans or more, is referred to there as the "Maracanazo", a national tragedy still felt today.
Falke的最终失利令人扼腕,但eBay的表现确实无可匹敌。我以为自己对eBay的爱将矢志不渝,因为鄙人全部的穿戴和家中物件均来自这家公司,而它却向《纽约时报》(the New York Times)表示:“我们热切希望利用我们的平台,通过营造公平的竞争环境来造福数百万人。”
Usher “Good Kisser” (RCA)
以下是第68届年度黄金时段艾美奖的主要获奖者名单,请登陆emmys.com浏览获奖名单完整版。
JINX: THE LIFE AND DEATHS OF ROBERT DURST (HBO, Feb. 8) Andrew Jarecki (“Capturing the Friedmans”) directed this six-part documentary series with the cooperation of Mr. Durst, the New York real estate scion linked to several killings and the unsolved disappearance of his first wife.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

2.告诉你的朋友在世界杯期间无论如何也不要忙着生孩子、结婚或办丧事,因为我们是不会去的。
['epik]

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

According to the announcement, the new administrative center in Tongzhou will put infrastructure upgrades and ecological improvement on top of the agenda. The municipal government hopes to improve public services in education, healthcare, cultural events and industries in the district.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

Chicago-based rival AT Kearney is also preparing for a change at the top, with a vote to replace Johan Aurik, who has already served the maximum two terms as managing partner, due to take place in the first quarter of 2018. His replacement will be expected to focus on how to pull AT Kearney out of the ranks of mid-sized players.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

卓越雇主排名:66
Millward Brown的BrandZ估值主管Elspeth Cheung表示:“排行榜10强过去由消费品主宰。今年是科技。”
“These kinds of questions are really front and center, even though they’re not necessarily verbalized.”
Index: 93.6

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

“世界各地的政策制定者认识到美联储的决定将产生什么影响,为此忧心忡忡,这让我们担心,”百达资产管理公司(Pictet Asset Management)全球新兴债券部门主管Simon Lue-Fong表示。“人们在说美联储的决定已被反映到价格上,但既然没人知道究竟会发生什么,这怎么可能呢。”
“一国两制”的实践要不动摇、不走样、不变形。
But economists generally expect the momentum of the recent past to resume and continue once storm distortions abate. The 45 economists who responded to The Wall Street Journal's latest monthly forecasting survey saw the jobless rate falling to 7.8% by next June and 7.5% by the end of 2013. Some say job growth could accelerate from its slow pace. 'I think businesses are going to have to hire,' said Bob Baur, an economist with Principal Global Investors.[qh]
On Tuesday Saarland became the first German region to ban campaigning by foreign politicians. Several German local councils had called off planned Turkish ministers’ campaign meetings on technical grounds, such as fire safety.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
From the themed collection: 高端五金配件助力智能化
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

5月30日,日本南部海岸附近发生了强烈地震,使中国民众担心,继2011年后,类似海啸和福岛核电站熔融的大灾难会再次发生。不过,最后并没有出现人员死亡或重大损毁的报道。
新年英文祝福语大全

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

另外一件性玩具则显然属于中国皇室。
第十步 如果以上几条都做不到——就公告天下说你有反社会人格
最佳迷你剧集/电影类导演:苏珊娜?比埃尔(Susanne Bier),《夜班经理》(The Night Manager)
补救办法:这也是一个后知后觉的遗憾,没有时间机器是无法解决的。你在学业上花费的时间、精力和金钱是既定成本。你无法改变以前的学业情况,但可以找出自己在大学期间没有学好的课程,然后想办法从现在开始弥补。例如,如果你觉得自己在课堂外的社交有所不足,你可以考虑加入校友协会,或者努力地融入到你所在领域的行业协会。如果你后悔错过了早上八点钟的管理会计课程,悲叹这些知识现在对你多么重要,那么你可以看看附近社区大学的这类课程。
*最佳综艺节目台本创作:《约翰?奥利佛上周今夜秀》(Last Week Tonight With John Oliver)

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
From the themed collection: 宜家大手笔投资商业地产
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

Company: BlogHer
威尼斯被普遍认为是世界上最浪漫的城市之一,也是许多游客必来的水上城市。
克里斯汀“伯德小姐”是一名高中生,她“家里贫困拮据”,但却向往冒险成熟的生活,憧憬机遇的来临。但在她所就读的萨克拉门托天主教学院她却什么也寻求不到。影片讲述了主角高三一年的经历,包括她第一次恋爱,她在学校参加舞台表演,以及最重要的,她申请大学的故事。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 住建部:稳地价 稳房价 稳预期
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

仿佛是2016年对中国员工还不够艰难,一项年度调查披露,中国逾半数白领雇员在即将到来的(开销巨大的)农历春节假期来临前没有领到年终奖。
数据显示,三星仍然占据榜首,其次是苹果。但是即便如此,这前两名的科技公司的出货量却分别下降了3%和7%,全球市场份额出现了下滑。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

Chinese consumer prices rose in January, an encouraging sign for the world’s second largest economy in a month characterised by turbulence in its financial markets.
我的核心价值观是什么?作为一个人,对你来说什么是重要的?家庭、健康、信仰、工作还是其他?确保在你的生活中,你追寻了自己最在乎的东西。
[k?:n]

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 南京黏土砖瓦窑退出历史舞台
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

● 一群非法投票人在六个投票点出现给希拉里投票,你们还以为选民骗局是假的吗?
中国商务部(Ministry of Commerce)表示,今年1-10月中国对外投资总计863亿美元。
该剧在拍摄武术场景时使用的慢动作手法赢得不少好评。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

From the themed collection: 特色小镇发展开始“做减法”
Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Overall, 36 percent point to end times and 63 percent to climate change.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

节目13 歌曲《嫦娥》,李玉刚 景海鹏 刘旺 刘洋

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
From the themed collection: 两家中介被暂停朝阳网签资格
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

China's 2016 office box sales are expected to exceed the 2015 total of 44 billion yuan (6.8 billion U.S. dollars), the country's film watchdog said.
尽管俄罗斯假装把再平衡的重点转向亚洲,但是从其对乌克兰的做法可以看出,它仍然在权衡自己的力量以对抗西方,尤其是美国。

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

Stand: Apple CEO Tim Cook fought for workplace protection for the LGBT community
调查指出,关键的是,世界的不稳定性和冲突可能继续推动通货膨胀并影响某些城市的生活成本。
对欧洲的新投资比2014年的180亿美元高出28%,相比之下,2014年投资额较2013年翻了一倍。对美国的投资比2014年的128亿美元高出17%。
现在,她主要在模特行业发展,但是她也很希望跻身演绎圈。

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

Sometimes bosses suck. But if your boss sucks all the time and takes advantage of your time, it's time to find a new job.
"While most Chinese brands remain unknown to the outside world, within China they are establishing themselves with ever more sophisticated campaigns," said Rupert Hoogewerf, Hurun Report chairman and chief researcher.

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

[ai'dentik?l]
Producer prices, which are often regarded as a proxy for medium-term inflation, remained in negative territory, but the pace of decline improved.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

And this year, the Nobel Prize has defied the convention of celebrating big by presenting the biggest prizes to discoveries on the smallest scales.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

adj. 不稳定的,易变的
Horowitz, speaking to radio station RTE, said he was keen to keep the new Bond true to the 1950s creation.
vt. 谣传
“尽管这两位研究人员彼此独立工作,但夏普利的基本理论和罗斯的实证调查、实验和实用的设计相结合,产生了一个蓬勃发展的研究领域,并改善了很多市场的功能,”皇家研究院说。

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

总部位于广东的房地产开发企业碧桂园集团现年35岁的女继承人杨惠妍以485亿元的身家紧随其后。
“欧洲工商管理学院极大地充实了我们的跨文化体验,”一位来自瑞士的校友在接受调查时表示,“在这里学习全球文化好于其他任何地方。”

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
From the themed collection: 家居卖场无条件退货藏“猫腻”
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

伯利兹城靠近墨西哥和加勒比海,各处都是露天的街头小吃摊,为游客们提供了很多较实惠的用餐选择。
下面是我对2010年美国经济以及市场前景最乐观也是最终的猜测。
不断上演的进球大战正是本届世界杯精彩绝伦之处。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

We will ensure workplace safety and people's lives.
上述消息源还称,苹果将在明年10月发布一款12.9英寸的平板电脑,“目标消费群是北美的教育市场(和)……生产商是广达电脑(Quanta Computer)”。有报道称,三星也在研发尺寸在12至13英寸之间的平板电脑,而现在看来,“这些大尺寸平板电脑将极大地影响超极本需求”几乎是板上钉钉的事了。新款“iPad Max”,搭载整合了键盘和电池的新款外壳之后,实际上就是一台笔记本电脑,很有可能在高中生和大学生之中成为主流产品——这一人群需要比现有iPad和iPad Mini产品更好的内容创造工具。
Add your scores for questions one to nine to see how you score on the Negative Affectivity scale

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

This quiet, intense Israeli film unfolds like a psychological thriller. A poetry-loving teacher discovers that one of her young pupils is a literary prodigy, and takes increasingly extreme measures to protect his gift from an indifferent world. As the story unfolds, it becomes clear that Mr. Lapid is engaged in a stealthy, ferocious critique of a society that has sacrificed its spiritual values and its cultural inheritance on the altar of power and materialism.
[r?'m?ntik]

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

由于孙轶潇没带手机,他开始尝试大声呼救以引起外面人的注意,但是时间一分一秒地流过,并没有人回应他。
学校依赖于多种多样的技术,确保授课的活泼和互动性,包括虚拟课堂、直播授课以及多媒体教学资料。校友们被要求对授课质量进行评价,并说明在线考试的效果如何。结果令人鼓舞。在线授课质量似乎越来越好。在线授课所有方面的得分都比前几年高,这表明学员满意度提高。
And, thanks to Artnet and other databases that list auction results, wealthy people who buy art have become all too aware of how hard it is to make a profit on old masters.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

3.贫穷
Gov. Ricardo Rossello, 37, proposed several measures aimed at alleviating the crisis shortly after he was sworn in at midnight. Among them is a proposal to hold a referendum that would ask voters whether they prefer statehood or independence. Many have argued that Puerto Rico’s political status has contributed to its decade-long crisis that has prompted more than 200,000 people to flee to the U.S. mainland in recent years.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
From the themed collection: 科勒在海口开设大型展厅
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

'Nebraska' gets to the heart of Bruce Dern's prickly old geezer, Woody Grant, by way of a road trip across Montana and Nebraska, shot in radiant black-and-white. (Here again one of the movie's stars is its cinematographer, Phedon Papamichael.) Alexander Payne directed, flawlessly, from Bob Nelson's stellar script, which is all about thwarted love, and reconciliation, between Woody and his son Will; he's played with painfully quiet eloquence by Will Forte. Here's the American heartland as it's seldom portrayed on screen, with humor and almost palpable fondness.
根据北京市统计局发布的一份报告显示,2015年北京市社会消费品零售总额突破万亿元,达到了10338亿元,同比增长7.3%。
No. Football punditry is a mug’s game. Better to have the benefit of hindsight. There have been 20 previous World Cups. Of those, Brazil (five titles) and Germany (four), are regular contenders. Home advantage helps, with host nations winning the trophy six times. But next year’s festival of football is being held in Russia, which has the lowest-ranked team in the tournament.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 广州:厨房阳台不得租给人居住
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Theresa May is still facing resistance from within her own party. Vince Cable, the Liberal Democrats’ sage and leader, still thinks Brexit may not really happen.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
From the themed collection: 样品家具“低价”下猫腻多多
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

Newcomers: Among the 15 newcomers on this year’s list are South Korean President Park Guen-hye (No. 11); Lockheed Martin CEO Marillyn Hewson (No. 34); CEO Tory Burch (No. 69); Spanx founder Sara Blakely (No. 90) and Baidu CFO Jennifer Li (No. 98).
肯尼迪中心为她的善举给她颁发了希望的波澜奖(the Ripple of Hope Award),泰勒也成为此奖项的最年轻获得者。

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

Wealthy Chinese bought at least seven overseas islands in 2014.
谷歌和亚马逊分居第二、三名。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

4.美国电话电报公司
The house is on a slight hill above the street. Its entry is a large glassed porch with a brick floor and walls of windows facing the lake. The renovation preserved coffered ceilings and the abundant use of wood in the original part of the house. The floor plan is open, and nearly every room has views of the lake through picture windows.

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

5.《出租车司机》
Although Guo has not given any timetable for her retirement, her announcement at December's East Asian Games about a possible one-year hiatus is a clear enough signal. From all evidence, her relationship with Fok seems to have entered another stage. Unless they truly believe that the Chinese lunar calendar warns against a "widow's year" in 2010, we might well see Miss Guo become Mrs Fok.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Morgan Stanley CEO James Gorman will do an about-face on the bank's 'lower risk' corporate strategy.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

[slu:]
清华大学位列第45名,是亚洲排名第三的高校。北京大学位居第57位。浙江大学排名第67位,本次是该校首次跻身该榜单100强。
Define yourself
Sure, Chris Paul is a bit bigger and stronger now, but he still looks almost identical to the way he did in high school. He even had his trademark mustache back in high school.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
From the themed collection: 房地产广告牛皮是如何吹大的?
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

However, 2016 saw the rise of Chinese mobile phone-makers. Huawei shipments grew 30.2 percent year on year to 139.3 million units, and the company retained its No. 3 position globally.

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

Some smart beds will promise you better sleep and posture, but this one in particular will turn you into a private investigator looking to catch a cheating spouse in the act. Regardless of knowing if it's comfortable, the Smarttress alerts you "whenever someone is using your bed in a questionable way."
库克的缺乏表现欲,并不总被视为一种优点。
n. 沼地,极多,回转 n. 大量,许多 v. 使转,扭

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

这部电影有实力冲击很多奖项,但很难领跑其中的任何一项。也许“甜茶”蒂莫西?柴勒梅德的表演是该片冲奥的最大可能。
加拿大学校继续失利。今年的上榜学校只有3所,而去年为5所,而且这3所学校的排名都下降了6个位次左右。多伦多大学(University of Toronto)罗特曼商学院(Rotman School of Management)排名最高,为第65位,而加拿大女王大学(Queen’s University)史密斯商学院(Smith School of Business)在今年的榜单中垫底,排名第100。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

就在一个月前,近200个国家的政府在巴黎达成了一项新的气候协议,目标是阻止全球气温比工业化前水平上升2摄氏度以上,最好限制在1.5摄氏度以内。
Twenty-something show

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

3.会飞的自行车

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

n. 日历,月历,日程表
别让自己工作得太舒服
在接下来几年里,大型住宅楼盘必须遵守第87号本地法(Local Law 87)——该法要求楼盘审核能源使用量,并保持系统以最高效率运行。住宅楼是纽约市最大的温室气体排放源,其排放量占总量的37%。“能源是一大热门话题。楼盘怎样提高能源效率?”管理着超过500处房产的FirstService Residential New York的总裁丹·沃泽尔(Dan Wurtzel)说,“如果运营预算的三分之一来自能源耗费,而现在你可以降低这块成本,那么上涨维护费的压力就减轻了。”

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Topped with golden leaves and flavored with champagne, the confection was sold for $100 a pop.
Yes. With the US Federal Reserve likely to raise interest rates a few times in 2018, trading is likely to be choppy in emerging markets. Sometimes it may feel a bit like a rerun of the 2013 “taper tantrum”. However, average GDP growth will rise to 5 per cent, up from a forecast 4.7 per cent this year. This will mostly be because Russia and Brazil, which have stumbled, will bounce back.
This was never more powerful than when he talked publicly for the first time about his sexuality.
“能被评为全球最国际化的大学之一,这个名单中的所有学校都是值得祝贺的。这标志着它们拥有巨大的潜力、竞争力和发展动力。”

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

去年他在一次采访中表示,“除了其他人”,他还会把他的财产赠予邱佩特。
8) Let Me Think About That: Yeah, it sounds like a cop out. And it is…sometimes. Fact is, we don’t always have the authority or expertise to make decisions. This phrase buys you time and breathing space. Then, set a date and time for follow up so the other person knows you’re taking him serious.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Let’s now travel to Greece. There, Andreas Georgiou, the head of its statistical agency between 2010 and 2015, faces prosecutions for his part in uncovering fake Greek public finance data for 2009 and setting the record straight. This week 40 groups, led by the American Statistical Association, and 651 individuals signed a statement in support of Mr Georgiou.
"As a native of Shaanxi, I found Sun played the role well. She jumps and runs wildly, just like a typical young naughty Shaanxi girl," a netizen Xuelili said.
照片左起分别是苹果董事长史蒂夫乔布斯,总裁兼CEO约翰斯卡利,创始人之一的斯蒂夫沃兹尼亚克,他们正在推出新款苹果II c型机,1984年4月24日,旧金山

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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About this collection

3. You support the teams that I support.
A series of explosions on Aug. 12 that originated in a warehouse illegally storing hazardous chemicals in the port city of Tianjin killed 173 people, injured hundreds and left behind post-apocalyptic scenes of destruction. The blasts raised serious questions about the lax enforcement of safety regulations during China's rapid industrialization.

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